Eric Schoen

D.O.B: August 30, 1956


KU Leuven, Faculty of Bioscience Engineering / Guest Professor

2018 - present

Dutch Organization of Applied Scientific Research TNO, Zeist / Senior Statistical Consultant

1987 - 2020

University of Antwerp, Faculty of Applied Economics / Guest Professor

2006 - 2017

Eindhoven University of Technology, Dept. of Mathematics and Computer Science / Researcher


Erasmus University, Rotterdam, Institute of Public Health and Social Medicine / Scientific Researcher


Vrije Universiteit, Amsterdam, Dept. of Biology / Scientific Assistant



Eindhoven University of Technology / PhD Applied Statistics


Vrije Universiteit Amsterdam / MSc Theoretical Biology


Vrije Universiteit, Amsterdam / BSc Biology and Chemistry


Refereed publications

  1. Schoen, E.D., Jager, J.C., van Verseveld, H.W., and Stouthamer, A.H. (1985) Statistical analysis of growth limitations in Paracoccus denitrificans: an experiment with a completely randomized two-way factorial design with replications. Antonie van Leeuwenhoek 51: 11-24.
  2. Arts, J.H.E., Zwart, A., Schoen, E.D., and Klokman-Houweling, J.M. (1989) Determination of concentration-time-mortality relationships vesus LC50s according to OECD guideline 403. Experimental Pathology 37: 62-66.
  3. Zwart, A., Arts, J.H.E., Klokman-Houweling, J.M., and Schoen, E.D. (1990) Determination of concentration-time-mortality relationships to replace LC50 values. Inhalation Toxicology 2: 105-117.
  4. Smeets, J.F.M., Odink, J., Visser, I.J.R., Schoen, E.D., and Snijders, J.M.A. (1990) Haematology and blood-chemistry for predicting abscesses and other abnormalities in slaughtered pigs. The Veterinary Quarterly 12: 146-151.
  5. Wolff, K., Schoen, E.D., and Peters – van Rijn, J. (1993) Optimizing the generation of random amplified polymorphic DNA in chrysanthemum. Theoretical and Applied Genetics 86: 1033-1037.
  6. Schoen, E.D. (1996) Statistical designs in combination toxicology: a matter of choice. Food and Chemical Toxicology 34: 1059-1065.
  7. Groten, J.P., Schoen, E.D., and Feron, V.J. (1996) Use of factorial designs in combination toxicity studies. Food and Chemical Toxicology 32: 1083-1089.
  8. Groten, J.P., Schoen, E.D., van Bladeren, P.J., Kuper, C.F., van Zorge, J.A., and Feron, V.J. (1997) Subacute toxicity of a combination of nine chemicals in rats: detecting interactive effects with a fractionated two-level factorial design. Fundamental and Applied Toxicology 36: 15-29.
  9. Schoen, E.D., and Wolff, K. (1997) Design and analysis of a fractional 4^13^12^5 split-plot experiment. Journal of Applied Statistics 24: 409-419.
  10. Groten, J.P., Tajima, O., Feron, V.J., and Schoen, E.D. (1998) Statistically designed experiments to screen chemical mixtures for possible interactions. Environmental Health Perspectives 106, Suppl 6: 1361-1365.
  11. Schoen, E.D. (1999) Designing fractional two-level experiments with nested error structures. Journal of Applied Statistics 26: 495-508.
  12. Maas, W.J.M., de Graaf, I.A.M., Schoen, E.D., Koster, H.J., van de Sandt, J.J.M., and Groten, J.P. (2000) Assessment of some critical factors in the freezing technique for the cryopreservation of precision-cut rat liver slices. Cryobiology 40: 250-263.
  13. Schoen, E.D., and Kaul, E.A.A. (2000) Three robust scale estimators to judge unreplicated experiments. Journal of Quality Technology 32: 276-283.
  14. Tajima, O., Schoen, E.D., Feron, V.J., and Groten, J.P. (2002) Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions. Food and Chemical Toxicology 40: 685-695.
  15. Bingham, D.R., Schoen, E.D., and Sitter, R.R. (2004) Designing fractional factorial split-plot experiments with few whole-plot factors. Journal of the Royal Statistical Society Series C 53: 325-339; Corrigendum: Journal of the Royal Statistical Society Series C 54: 955-958.
  16. Schoen, E.D. (2004) Dispersion-effects detection after screening for location effects in unreplicated experiments. Journal of Statistical Planning and Inference 126: 289-304.
  17. Feron, V.J., Groten, J.P., Hermus, R.J.J., Jonker, D., Meijerman, I., Mulder, G.J., Salmon, F., and Schoen, E.D. (2005) Designing experiments for food-drug synergy: safety aspects. In: Food-drug synergy and safety (L.V. Thompson and W.E. Ward, editors; Boca Raton: CRC/Taylor & Francis).
  18. Schoen, E.D. (2009) All orthogonal arrays with 18 runs. Quality and Reliability Engineering International 25: 467-480.
  19. Schoen, E.D., Eendebak, P.T., and Nguyen, M.V.M. (2010) Complete enumeration of pure-level and mixed-level orthogonal arrays. Journal of Combinatorial Designs 18: 123-140.
  20. Schoen, E.D. (2010) Optimum designs versus orthogonal arrays for main effects and two-factor interactions. Journal of Quality Technology 42: 197-208.
  21. Schoen, E.D., Goos, P., and Jones, B. (2011) A split-plot experiment with factor-dependent whole plot sizes. Journal of Quality Technology 43: 66-79.
  22. Schoen, E.D., and Mee, R.W. (2012) Two-level designs of strength 3 and up to 48 runs. Journal of the Royal Statistical Society Series C 61: 163-174.
  23. Sartono, B., Goos, P., and Schoen, E.D. (2012) Classification of three-level strength-3 arrays. Journal of Statistical Planning and Inference 142: 794-809.
  24. Schoen, E.D. (2012) Designs for two-stage intensive screening of pharmaceutical production processes. Statistics in Biopharmaceutical Research 4: 336-347.
  25. Schoen, E.D., and Van der Voort Maarschalk, K. (2012) Adding a factor in the course of a design space characterization. Journal of Pharmaceutical Innovation 7: 163-173.
  26. Schoen, E.D., Sartono, B., and Goos, P. (2013) Optimum blocking for general resolution-3 designs. Journal of Quality Technology 45: 166-187.
  27. Schoen, E.D., Rubingh, C.M., Wopereis, S., and Van Erk, M. (2013) Controlling false discovery rates in factorial experiments with between-subjects and within-subjects tests. BMC Research Notes 6: 204.
  28. Garai, M., Schoen, E., Behler, G., Bragado, B., Chudalla, M., Conter, M., Defrance, J., Demizieux, P., Glorieux, C., and Guidorzi, P. (2014) Repeatability and reproducibility of in situ measurements of sound reflection and airborne sound insulation index of noise barriers. Acta Acustica / Acustica 100: 1186-1201.
  29. Schoen, E.D., and Goos, P. (2015) Discussion on ‘The case against normal plots of effects’. Journal of Quality Technology 47: 114-118.
  30. Sartono, B., Goos, P., and Schoen, E.D. (2015) Blocking orthogonal designs with mixed integer linear programming. Technometrics 57: 428-439.
  31. Sartono, B., Goos, P., and Schoen, E.D. (2015) Constructing general orthogonal fractional factorial split-plot designs. Technometrics 57: 488-502.
  32. Jones, B., Schoen, E.D., and Montgomery, D.C. (2016) A comparison of two-level designs to estimate all main effects and two-factor interactions. Quality Engineering 28: 369-380.
  33. Eendebak, P.T., and Schoen, E.D. (2017) Two-level designs to estimate all main effects and two-factor interactions. Technometrics 59: 69-79.
  34. Mee, R.W., Schoen, E.D., and Edwards, D.J. (2017) Selecting an orthogonal or nonorthogonal two-level design for screening. Technometrics 59: 305-318.
  35. Kooter, I.M., Gröllers-Mulderij, M., Duistermaat, E., Kuper, F., and Schoen, E.D. (2017) Factors of concern in a human 3D cellular airway model exposed to aerosols of nanoparticles. Toxicology in Vitro 44: 339-348.
  36. Schoen, E.D., Vo-Thanh, N., and Goos, P. (2017) Two-level orthogonal screening designs with 24, 28, 32, and 36 runs. Journal of the American Statistical Association 112: 1354-1369.
  37. Vo-Thanh, N., Jans, R., Schoen, E.D. and Goos, P. (2018) Symmetry breaking in mixed integer linear programming formulations for blocking two-level orthogonal experimental designs.  Computers & Operations Research 97: 96-110.
  38. Schoen, E.D., Eendebak, P.T., and Goos, P. (2019) A classification criterion for definitive screening designs. The Annals of Statistics 47: 1179-1202.
  39. Schoen, E.D., Vo-Thanh, N., and Goos, P. (2019) Orthogonal blocking arrangements for 24-run and 28-run two-level designs. Journal of Quality Technology 51: 143-158.
  40. Goos, P. and Schoen, E.D. (2019) Discussion Discussion on “Søren Bisgaard’s contributions to Quality Engineering: Design of experiments”. Quality Engineering, 31: 157-161.
  41. Vazquez, A.R., Goos, P., and Schoen, E.D. (2019) Constructing two-level designs by concatenation of strength-3 orthogonal arrays. Technometrics 61: 219-232.
  42. Vazquez, A.R., Goos, P., and Schoen, E.D. (2020) Projections of definitive screening designs by dropping columns: selection and evaluation. Technometrics 62: 37-47.
  43. Vo-Thanh, N., Schoen, E.D., and Goos, P. (2020) Row-column arrangements of regular and nonregular fractional factorial two-level designs. Journal of Quality Technology 52: 304-322.
  44. Vo-Thanh, N., Goos, P. and Schoen, E.D. (2020) Integer programming approaches to find row–column arrangements of two-level orthogonal
    experimental designs. IISE Transactions 52: 780-796.
  45. Schoen, E.D. and Wopereis, S. (2020) A new randomization procedure based on multiple covariates and applicable to parallel studies with simultaneous enrollment of all subjects prior to intervention. BMC Medical Research Methodology 20: 222.
  46. Vazquez, A.R., Schoen, E.D. and Goos, P. (2021) A mixed integer optimization approach for model selection in screening experiments. Journal of Quality Technology 53: 243-266.
  47. Vazquez, A.R., Schoen, E.D. and Goos, P. (2021) Two-level orthogonal screening designs with 80, 96, and 112 runs, and up to 29 factors. Journal of Quality Technology, in press.
  48. Kort, R., Schlösser, J., Vazquez, A.R., Atukunda, P., Muhoozi, G.K.M., Wacoo A.P., Sybesma W.F.H., Westerberg A.C., Iversen P.O., and Schoen E.D. (2021) Model Selection Reveals the Butyrate-Producing Gut Bacterium Coprococcus eutactus as Predictor for Language Development in 3-Year-Old Rural Ugandan Children.  Frontiers in Microbiology 12: 1406.


American Society for Quality, Statistics Division: Lloyd Nelson Award 2011.


  1. European Congress on Combination Toxicology, Velthoven, Netherlands: ‘Statistical Designs in Combination Toxicology: a Matter of Choice’ (October 11-13, 1995).
  2. Spring Research Conference (SRC) 2002, Ann Arbor, MI, USA: ‘Fractional Split-Plot Experiments with Replicated Settings of Whole-Plot Factors’ (May 20-22, 2002).
  3. DAE 2005, Sante Fe: ‘Enumeration and Selection of Small Orthogonal Strength-3 Arrays’ (October 12-14, 2005).
  4. Workshop of the Belgian Branch of the European Network for Business and Industrial Statistics (bENBIS), Antwerp: ‘Two-Level Fractional Factorial Split-Plot Designs’ (June 2, 2006).
  5. 2006 International Conference on Design of Experiments and Its Applications, Tianjin, China: ‘Orthogonal Arrays of Strength 3 with Full Estimation Capacities’ (July 9-13, 2006).
  6. DEMA 2008, Cambridge, UK: ‘A blocking strategy for orthogonal arrays of strength 2’ (August 11-15, 2008)
  7. Workshop on Quality Improvement Methods, University of Dortmund, Germany: ‘Very fast enumeration of orthogonal arrays’ (May 22-23, 2009).
  8. ENBIS 2010, University of Antwerp, Belgium: ‘Optimum designs versus orthogonal arrays’ (September 13-15, 2010).
  9. ICODOE 2011, University of Memphis, Memphis TN, USA: ‘Better alternatives than generalized aberration to select strength-three multi-level designs’(May 11-13, 2011).
  10. DEMA 2011, Cambridge, UK: ‘Split-plot experiments with factor-dependent whole plot sizes’ (August 30-September 2, 2011).
  11. Fall Technical Conference 2011, Kansas City MO, USA: ‘Mixed-level designs for main effects and two-factor interactions: generated from scratch or catalog based?’ (October 13-14, 2011).
  12. JSM 2013, Montreal Québec, Canada: ‘Constructing general orthogonal fractional factorial split-plot designs’ (August 3-8, 2013).
  13. Spring Research Conference 2016, Chicago IL, USA: ‘Two-Level Designs to Estimate All Main Effects and Two-Factor Interactions’ (May 25-27, 2016)
  14. Conference on Experimental Design and Analysis 2018, Hsinchu, ROC: ‘A connection between orthogonal two-level designs and Definitive Screening Designs’ (December 13-15, 2018)
  15. 8th International Conference on Risk Analysis and Design of Experiments, Vienna, Austria: ‘A connection between orthogonal two-level designs and Definitive Screening Designs’ (April 23-26, 2019)

PhD students

  • Man Nguyen: Computer algebraic methods for the construction of designs of experiments. PhD thesis Eindhoven University of Technology, October 2005 (co-advisor).
  • Bagus Sartono: Orthogonal experimental designs under complete and restricted randomization. PhD thesis University of Antwerp, May 2012 (advisor).
  • Nha Vo-Thanh: Two-level orthogonal experimental designs in the presence of zero, one or two blocking factors. PhD thesis University of Antwerp, September 2016 (advisor).
  • Alan Vazquez, University of Antwerp: Orthogonal experimental designs for screening: construction and analysis. PhD thesis University of Antwerp, May  2018 (advisor).

MSc students

  • Enrico Kaul
  • Peter van den Berg
  • Volkert Siersma
  • Ruben Snepvangers
  • Vincent Brouérius van Nidek